Associations between plasma tenofovir concentration and renal function markers in HIV-infected women

Associations between plasma tenofovir concentration and renal function markers in HIV-infected women

Background Tenofovir disoproxil fumarate (TDF) has been associated with kidney tubular dysfunction and reduced renal function. Limited studies were performed in Europe and Asia that related plasma tenofovir (TFV) concentration with renal function; no such studies to date have been performed on Africans. Objective To investigate the correlation between plasma tenofovir (TFV) concentration and ...

Renal function in HIV-infected children and adolescents treated with tenofovir disoproxil fumarate and protease inhibitors

BACKGROUND Kidney disease is an important complication in HIV infected people, and this may be related to infection or antiretroviral therapy (ART). Our aim is to assess renal function in HIV infected paediatric patients, who may be particularly affected and are likely to take ART for longer than adults, and investigate the long term role of Tenofovir Disoproxil Fumarate (TDF) alone or co-admin...

Impact of tenofovir on renal function in HIV-infected, antiretroviral-naive patients.

OBJECTIVE To better characterize the long-term effects of tenofovir on renal function in a large managed care organization. METHODS We performed a retrospective cohort analysis in Kaiser Permanente for years 2002 to 2005 comparing renal function among antiretroviral naïve patients initiating a tenofovir-containing regimen (964 patients) or tenofovir-sparing regimens (683 patients). We evaluat...

Renal safety of tenofovir in HIV-infected patients who switch from stavudine or zidovudine to tenofovir

The effect of tenofovir on renal function in HIV-positive pregnant women

INTRODUCTION Tenofovir is a commonly used component of antiretroviral therapy (ART) to reduce vertical transmission of HIV. Although systematic review of tenofovir use in pregnancy concluded it to be low risk for foetal abnormalities (1), data is limited on its impact on renal function in pregnant women. A recent South African study (2) concluded that renal dysfunction in HIV-infected pregnant ...